Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. ALS accounts for about 70% of all cases of motor neuron disease and one of the first symptoms to appear is progressive muscle weakness and atrophy of the muscles of the extremities followed by bulbar symptoms. Muscle atrophy occurs gradually and eventually affects all muscles. The bulbar form of the disease progresses much faster and within 2 to 3 years respiratory problems and cessation of breathing occur. Survival in the spinal form is slightly longer, 3 to 5 years, while the average age at which people get the disease is 56 years. The prevalence of ALS in the European population and the population of European origin is estimated to be 2.6-3 ALS patients per 100,000 people. In 95% of cases, ALS appears sporadically, but in 5 to 10% there is a positive family history. Approximately 70% of patients have the spinal form affecting the upper and/or lower limbs, about 25% of patients have the bulbar form, and the remaining 5% have isolated respiratory muscle weakness accompanied by symptoms such as dyspnea, insomnia, anorexia and possible death. Establishing a diagnosis is made by taking a quality medical history, which includes specific questions about symptoms that occur in certain regions. The main purpose of treatment is to prevent and alleviate complications that occur in patients and to encourage greater independence in the patient's daily life. The most common nursing diagnoses that occur are reduced ability to selfcare, reduced airway patency, and reduced exertion, and potential nursing diagnoses are high risk for falls, high risk for pressure ulcers, and high risk for infection. As the disease progresses, health care itself becomes more and more complex and demanding, and therefore the approach of the nurse should be adapted and individual to each patient. When creating a health care plan, you should adhere to the principles of health care and a holistic approach to the patient, respecting his mental and physical condition.