Objective: The objective of the research is to highlight the importance of nurses in the formation of attitudes about vaccination against COVID-19 in relation to the self-assessment of health and quality of life at the University of Split. Also, the aim of the paper is to determine whether the attitudes of students of health studies are more positive towards the vaccine compared to students of non-health studies, as well as the relationship to demographic characteristics. Methods and respondents: For the purposes of creating the empirical part of this work, a survey questionnaire was conducted among 315 students of the University of Split. When collecting data for this research, we used a two-part questionnaire. The first part of the questionnaire refers to demographic data and questions related to vaccination against COVID-19, the type of vaccine they received, i.e. whether they have recovered from COVID-19, and in the second part, the SF - 36 questionnaire was used to examine the general state of health of the respondents. Results: The results of the research in which the significance of the nurse in the formation of attitudes about vaccination against COVID-19 in relation to the self-assessment of health and quality of life of students of the University of Split was examined shows that half of the students who participated in the research received the vaccine against the COVID infection. The most commonly received vaccine is Pfizer, followed by Moderna and Astra Zeneca. Vaccinated subjects experienced at least one side effect. The most common reason for deciding to vaccinate is to protect your loved ones. The largest number of respondents who have not been vaccinated and do not intend to be vaccinated believe that the vaccine has not been sufficiently researched, while the smallest number of respondents are not vaccinated because they share the view that COVID-19 is a harmless disease. 73.57% of respondents got over the infection of COVID-19, as did their household members. The majority of respondents do not consider themselves as a member of the risk group. The highest quality of life of the examined students was found in physical functioning, while the lowest level of quality of life was found in the construct of energy and vitality. Conclusion: It can be concluded that the attitudes of students of health studies are more positive towards the vaccine compared to students of non-health studies. There is a difference in students' attitudes towards the vaccine against COVID-19 depending on whether they have recovered from COVID-19.