Due to the symptoms of a malignant disease, the quality of life is significantly reduced, causing disability. Due to the presence of pain, urinary and pelvic sepsis, obstruction, fistula formation, and a confirmed indication for surgery, multivisceral pelvic resections are performed due to locally extended malignant diseases. An improvement in the quality of life can be achieved, but there are significant complications and high morbidity due to the extensiveness of these procedures. A holistic approach to the patient is necessary with the aim of good education in the diagnosis, method of treatment, type of surgery, and improving the quality of life after surgery, where nurses play a more important role. As part of a multidisciplinary team, the nurse starts educating the patient in the preoperative period. The patient gains knowledge about changes in the appearance and function of their body and acquires skills in urostomy and colostomy procedures. Also, female patients might require the construction of a neovagina as a reconstruction procedure after a necessary resection. Adequate psychological preparation leads to better adaptation and a higher quality of life after surgery. In the postoperative period, recovery takes a long time, due to the complexity of the procedure. Patients may be stationed in the intensive care unit, and then they are transferred to the ward. By focusing on meeting the patient's basic needs, the nurse recognizes nursing diagnoses, and by implementing interventions, she orients herself toward the fulfillment of healthcare goals. With its knowledge and procedures, it encourages and helps the patient to mobilize, provides them adequate nutrition, control of the surgical wound, care and education for the urostomy or colostomy, and psychological support.