Diabetes is a chronic metabolic and progressive disease that has reached pandemic proportions. It is estimated that 10.5% of the world's population has diabetes, thus representing a global challenge that demands attention and creative strategies from healthcare systems worldwide. While macrovascular complications remain the leading cause of death in patients with diabetes, this study provides a detailed description of dermatological changes in patients with diabetes, with a particular emphasis on the severity of diabetic foot. Within the realm of dermatological manifestations, specific changes such as acanthosis nigricans, diabetic dermopathy, and xerosis are thoroughly described, which are characteristic of individuals with type 2 diabetes. Other manifestations are also analyzed, such as diabetic blisters, lipoid necrobiosis, and vitiligo, which are more common in individuals with type 1 diabetes. The study's special focus is directed towards the crucial role of the nurse in recognizing skin changes in individuals with diabetes. For this purpose, the study highlights the importance of continuous patient education regarding precise insulin application, while simultaneously emphasizing the need for regular systematic skin examinations, particularly in areas that are not easily visible to the patient, such as the feet or back. Nurse educators, in addition to providing education,, take on the responsibility, like physicians, for demonstrating self-examination skills or conducting joint examinations of these areas during consultations. At its core, the study calls for active partnership between healthcare professionals and individuals with diabetes to collectively address the challenges of diabetes and its complications, particularly in the form of dermatological changes.