Liver biopsy is an invasive method used in diagnosing of liver diseses; its purpose being a determining of a nature of the disease (diagnosis establishing), or assessing of a degree of the disease. This method is highly useful and reliable and relatively inexpensive, but also invasive and unpleasant for the patient. Despite certain risks for complications, this is a generally safe method for the patient. A successful liver biopsy requires specific knowledges and skills of a doctor and a nurse who perform the procedure. Equally important is an adequate psychologic approach to the patient, and, beside the doctor's, there is an especially important role of the nurse in it. In this study, conducted at the Department of gastroenterology, University hospital Split, trends and successfulness of a liver biopsy as well as its complications were analyed, and the role of the nurse in this procedure was assessed. Objective: To anlyze trends in percutaneous liver biopsy, its successfulness and complications rate in observed time period (2020.—2022.). Further aim was to compare biopsy resupts with initial diagnosis. Besides that, a role of the nurse in performing of the procedure was analyzed. Methods: Data are collected from hospital information system (BIS), hospital dicharge letters and from nursing documatation. The data are processed in Microsoft Excel application and presented using tables and graphs. Results: They indicate an increased freaquency of performing percutaneous liver biopsy during the observed period. A guided liver biopsy was performed more frequently than a blind biopsy. A successfulness of the liver biopsy was high and a correlation of biopsy results with initial diagnosis was significant, while complications rate was low.