Glioblastoma is the most severe type of human brain tumor that has a very low survival rate and a very poor prognosis. Patient survival rates have not improved despite advances in surgery and medicine. There are two types of glioblastoma: primary glioblastoma, which is more common and mostly affects older people, and secondary glioblastoma, which is rarer and more common in younger people. The signs and symptoms experienced by patients with glioblastoma vary depending on where the tumor is primarily located, as well as its size. Almost all patients have headache, nausea, double vision, dizziness, speech and motor problems, epileptic seizures and many other symptoms. Diagnosis usually begins with a detailed medical examination (neurological examination), radiological examinations (CT and/or MRI of the brain) and taking a tissue biopsy (stereotaxy). Treatment is usually very complex and includes a combination of surgical treatment, radiotherapy, chemotherapy and targeted drug therapy. In planning the health care of patients with glioblastoma, the most important is a holistic approach that includes the assessment and interventions of the nurse. In health care, the nurse/technician has an extremely important role as part of a multidisciplinary team, because she participates in all preparations for diagnostic tests, physical and psychological preparation of the patient for surgery and after it, application of prescribed therapy, maintenance of vital functions and monitoring of changes in the patient's behavior. In addition to great knowledge, a nurse must possess experience, skills and empathy because she is responsible for planning the patient's health care from the moment the patient is admitted to the hospital, until his return to the family.