Goals: Goals of this research were to explore and compare epidemiological and clinical characteristics of patients suffering from infectious diarrhea caused by Cl. Difficile with ones caused by C. jejuni/coli; determine and compare values of laboratory reports of patients; examine possibilities of nursing care in patients suffering from infectious diarrhea caused by Cl. difficile and C. jejuni/coli. Respondents and methods: There was a retrospective survey which covered 94 patients. There was data included in research from the medical history of patients hospitalized for infectious diarrhea caused by Cl. difficile and C. jejuni/coli in KBC Split, in period from 1st of January to 31st of December 2013. Demographic, epidemiological, clinical and laboratory data about patients were entered in the questionnaire (Annex 1) which was made for need of this research. Questionnaire was anonymous. Results: Patients suffering from Campylobacter spp. had abdominal pain more often and significantly higher body temperature compared to patients suffering from Cl. difficile infection. Patients suffering from Campylobacter spp. were hospitalized noticeably earlier during the disease compared to patients suffering from Cl. difficile infection. Patients suffering from Cl. difficile infection had significantly longer length of hospitalization, in average 23,5 days compared to 6,3 days which is the case in patients suffering from Campylobacter spp. (p < 0,001). Group of patients suffering from Cl. difficile infection was older in average 24,9 years compared to group of patients suffering from Campylobacter spp. Also, it was of statistical significance more frequent use of antibiotics, undergoing surgeries before diarrhea, as well as the presence of chronic diseases in patients suffering from Cl. difficile infection compared to patients suffering from Campylobacter spp. (p < 0,001). It was of statistical significance longer duration of diarrhea in patients suffering from Cl. difficile infection compared to patients suffering from Campylobacter spp., 12,7 days versus 4,4 days (p < 0,001). Patients suffering from Cl. difficile infection statistically had more relapses of infection compared to patients suffering from Campylobacter spp. (p = 0,004). Patients suffering from Cl. difficile infection were statistically less mobile, more often incontinent, and had more frequent urinary catheter and nasogastric tube compared to patients suffering from Campylobacter spp. (p < 0,001). In 28,7% (27 patients) cases this disease appeared as clinical infection while 9,6% (9 patients) died. Conclusion: Disease caused by Campylobacter spp. was more difficult at the beginning. Patients suffering from Cl. difficile infection were more demanding in further stages of disease compared to patients suffering from Campylobacter spp.; in treating the disease as well as in health care. Prevention of clinical infection caused by Cl. difficile is extremely important measure of reducing clinical morbidity and mortality, which reduces the length of hospitalization and the costs of hospital care.