Objective: The aims of the study are to investigate the total number of psoriatic patients treated with biological therapy and the distribution by age and sex of patients. Also investigate how long they have been suffering from psoriasis before introducing therapy, compare quality of life before and after the introduction of herbal therapy. Respondents: Respondents made a sample of patients treated in the dermatovenerology clinic of the Clinic for Skin and Sexual Diseases KBC Split. 95 respondents took part, of which 62 were men and 33 women. Methods: The questionnaire of the Clinic for Dermatovenerology on the dermatological index of quality of life was applied to the respondents and a questionnaire on the demographic data on respondents. For the purpose of research, the dermatological quality index of life quality DQLI (Dermatological Quality of Life Index) was used. DQLI is a scale that evaluates the impact of psoriasis on the everyday lives of patients; physically, socially and mentally. Data on the number of patients and age distribution according to age are shown with an absolute number and percentage. Data was entered into the Excel table, and then analyzed in the IBM SPSS statistical package at 23. In the processing we used the χ2 test, the Mann-Whitney U test, and the Wilcoxon test. The results were interpreted at the level of significance p <0.05. Results:. In the conducted research, the influence of psoriasis on the quality of life of patients has been proven. The median number of points in terms of the questionnaire after treatment has dropped by 3 points in women (z = 5.1, p <0.001) and 2 points in men (z = 6.9; p <0.001) in relation to the number of points before therapy. Women, although shorter the duration of the disease are more susceptible to appearance. As for the question of the question of personal relationships, the median answer to this question before biological therapy was 3 (min-max: 0-3) and after therapy 0 (min-max: 0-2). There was a drop in the median by 3 (z = 6.9; p <0.001. Conclusion: Prior to therapy, more than 74% of patients assigned 3 of the 10 questions from the DLQI questionnaire 3 points, which means that the disease very much affected the poor quality of life in each segment. After the treatment, 94% of the patients assigned 0 points to each of the 10 questions, which means a very good quality of life in each segment. 53 Key words: psoriasis vulgaris, DQLI (Dermatological Quality of Life Index), biological drugs.