Percutaneous coronary intervention with stent implantation has become standard procedure in patients with coronary disease. Stents make up more than 80% of the interventions in coronary angioplasty. Long-term results of stenosis are obstructed by restenosis due to the elastic "recoil", neoplastic hyperplasia and vessel remodeling. The revolutionary discovery that put the balloon spills and solids metal stents in a second plan, precisely because of the reduction of restenosis, is the discovery of drug-eluting stents (DES). That kind of stent consists of 3 components: stent, polymer, and drug. In first few days, the highest drug counts, and 90 days after there is no drug in the stent ; the patient now has a metal stent. Currently, there are two more drugs being used in the DES system; sirolimus and paclitaxel. Commercial stents with these drugs are Cypher stent with sirolimus and Taxus stent with paclitaxel. Cypher has the advantage of less incidence of angiographic restenosis. In addition to sirolimus and paclitaxel in DES systems as their antiproliferative drugs, their analogs are also used; everolimus (Xcience V) and zotarolimus (Endeavor stent, Resolute, Resolute Integrity and Resolute Onyx stent). Studies show that the lower thrombosis has Xcience V (everolimus stent) compared to Resolute (zotarolimus stent). The latest advancement in the treatment of coronary diseases is the BVS stent; biodegradable stent that disappear within two years, and blood vessels remain the same as before the disease. As with every new product, after the initial suspicion comes enthusiasm, then, after facing the problems, a more rational approach is expected. DES was a problem in the form of a bitter mortality after long follow-up. The reason was quickly noticed, there was a very late thrombosis in the stent, and it was attributed to the partial late epithelialization. This has caused a sharp reduction in the use of DES. As the minimal number of incidents has been compared to a huge number of positive effects, it is likely that time is needed to make rational conclusions, but there is a general conclusion that "DES are here, to stay".