Hepatitis C is the leading cause of morbidity and mortality associated with liver disease in the world. It is a hepatotropic virus, so the majority of its multiplication occurs in the hepatocyte. Incubation of the virus averages 6-7 weeks, and the range of clinical manifestations that can be diagnosed varies from asymptomatic elevations of aminotransferases, acute hepatitis, fulminant hepatitis, chronic hepatitis, cirrhosis of the liver with all its complications to recent hepatocellular carcinoma. Due to the quiet clinical course, most patients with hepatitis C do not even know they are infected and are not treated in time and are a source of infection for others. Since the discovery of the hepatitis C virus until today, great progress has been made in researching the genetic characteristics of the virus and its mechanism of pathophysiology, which has resulted in improved pharmacotherapy and more successful treatment outcomes and greater possibility of permanent cure. In 2014, the era of oral therapy began and the cure rate was higher than 90%, and the treatment time was shorter. This changes the activities of the nurse and the primary role is no longer health care but communication, empathy and creating a pleasant atmosphere for the patient. The nurse has a role in mediating between the patient and the physician which involves gathering the medical documentation required for the approval of a directly acting antiviral drug. In addition, the nurse educates the patient about the disease and how to transmit it, how to protect themselves and others from the potential transmission of the infection. It explains to him what the protocol is before the approval of a direct-acting antiviral drug and the start of therapy, what diagnostic tests need to be done and helps him gather the necessary findings to send a request to the hospital committee that will approve treatment. It is supported and monitored throughout the treatment process, all with the aim of making the treatment of a person suffering from chronic HCV and going through a difficult period of life as easy as possible.