Acute stroke is one of the leading causes of death in the world, but also among the leading ones when it comes to concomitant disorders and difficulties such as permanent disability. Strokes are divided into ischemic and hemorrhagic, and the ischemic area of the brain before an irreversible infarction called an ischemic penumbra and is a risk area can be saved by proper reperfusion within a limited time. Despite increasing knowledge and the constant study of stroke and its treatment, rtPA was until recently the only approved therapeutic option for the treatment of acute ischemic stroke. Today, the method of choice is mechanical thrombectomy because it shows a significantly better treatment outcome compared to i.v. thrombolysis and has a significantly broader time frame. Until now, the time frame for MT was within 6 hours, today it is known that patients with a small infarction and a favorable ratio of penumbra and infarction benefit from MT even after 6 hours, so that time frame is moved to 24 hours. Given the cost-benefit and results of recent studies that have found no significant difference in the use of stent-retrievers and aspiration catheters, aspiration should be the initial MT method that continues in case of failure as a combined technique.