Summary: Objective: The aim of this paper is to compare the frequency of interventions (examination) of patients who were treated at a certain admission diagnosis at the Department of Emergency Medicine of Split-Dalmatia County (ZHM SDŽ) in the year before (2019/2020) and in the year during (2020/2021) COVID-19 pandemic. Materials and methods: This retrospective study included all patients treated at the Department of Emergency Medicine from February 2019 to February 2021. Data on age, sex and diagnosis of patients by ICD-10 classification were collected from medical program e-Hitna. Results: A significant difference in the frequency of admission diagnoses in the pre-COVID period compared to the COVID period on a total sample of 214 862 subjects were found in classes R00-R99 (Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified) , S00-T98 (Injuries, poisonings and certain other consequences with external cause) and J00-J99 (Respiratory diseases) at the level of significance p <0.001. Furthermore, a significant difference was found in class I00-I99 (Diseases of the circulatory system) at the level of p = 0.001 while class H60-H95 (Diseases of the ear and mastoid processes) showed a significance of p = 0.002. In the pre-COVID period, a significant gender difference was found, where women had a higher number of admission diagnoses than men in classes N00-N99 (Diseases of the genitourinary system) (p = 0.001) and in class R00-R99 (p <0.001). In the same period, men differed significantly from women in the S00-T98 class at the p <0.001 level. In the COVID period, a significant gender difference was found, where men had a higher number of admission diagnoses than women in class S00-T98 at the level of p <0.001, while women had more admission diagnoses in classes R00-R99 at the level of p <0.001, I00-I99 at p = 0.001 and N00-N99 (p = 0.005). Conclusions: A larger number of patients were admitted to ZHM SDŽ in the year preceding the pandemic than in the year with the COVID-19 pandemic. Although COVID-19 is primarily a respiratory disease, more patients were admitted under this admission diagnosis in the year before the COVID-19 pandemic, which is probably due to organization of the health system (direct access to COVID-19 admissions) and the effect of isolation and self-isolation (less contact between people). Adherence to the principle of lockdown is also a likely factor that has contributed to a significant reduction in the number of injuries and poisonings (traffic accidents, trauma, work injuries...).