Objectives: The main goal of this work is the difference in the concentration of cortisol in the saliva of patients diagnosed with OLP compared to the control group of the investigated subjects and see if there is a difference in salivary cortisol concentration between men and women. Material and methods: The material used in the analysis of the image sample. The survey consisted of 60 respondents. 30 of them had oral lynchen planus (OLP), while the other 30 were the control group. Saliva samples were collected and analyzed by immunochemical ELISA method. A statistical analysis was made from the obtained dana. Results: In this study, the concentration of salivary cortisol was compared between two groups of subjects and the difference in concentration by gender. Their comparison was made and a slightly positive correlation was obtained. Conclusion: Statistical analysis showed that there is no significant difference in cortisol concentrations of OLP patients and control groups and that there is a weak connection