Myasthenia gravis is autoimmune disease of the neuromuscular junction characterized by antibodies against postsynaptic nicotinic acetylcholine receptors. The annual incidence of myasthenia gravis is approximately 30 new cases per million, and approximately 15-20%. It is a disease that can be effectively controlled with modern therapeutic lines, even achieving complete remission. The onset of the disorder may occur suddenly, and the symptoms may not be immediately recognized as myasthenia gravis. Plasmapheresis is a process in which the liquid part of blood, i.e. plasma, is separated from blood cells. Usually, the plasma is replaced by another solution. Venous access for plasmapheresis is either through a central venous catheter or large-lumen peripheral catheters. Plasmapheresis carries a risk of side effects, which are usually rare and generally mild. The nurse's role is to provide personalized, humanistic and comprehensive care for patients undergoing plasmapheresis. The nurse is responsible for performing the procedure with the appropriate equipment, enables patient education about the procedure, blood monitoring and patient status, and communication with other health professionals participating in the plasmapheresis procedure. The nurse is involved in procedures before, during and after plasmapheresis treatment. The main tasks of the nurse are to maintain and improve the standard of health care, efficient use of resources and improvement of the quality of life of individuals undergoing plasmapheresis and the provision of health services. Patient education is a key component of all nursing roles that must be provided to patients about the basic principles of the plasma exchange procedure. Continuous education of patients will help them overcome the negative aspects of their treatment, deal with their illness maturely, actively participate in the care plan and promote the maximum level of rehabilitation. Also, after the plasmapheresis procedure, the nurse should carry out procedures aimed at preventing potential infection in the patient and all other possible complications such as dizziness, nausea, bleeding and dehydration. The nurse must continuously monitor the patient, his vital functions and properly document everything and inform the competent doctor about changes