AIM: The aim of this thesis was to examine the impact of the COVID-19 pandemic on the burnout syndrome in medical workers of the Split Clinical Hospital Center. METHODS: Data were collected through an anonymous survey that examined the level of burnout syndrome according to the Burnout Intensity Questionnaire by Ajduković D. and Ajduković M. (1994) and the level of anxiety according to the Beck Anxiety Inventory (BAI) by Back AT., Epstein N., Brown. G., and Steer RA. (1988). The data was collected from January to April 2023 in online form. Each respondent which number was 101 was familiar with the aim of the research. Respondents participated on a voluntary basis and completely anonymously, and received an informed form through which they were informed about the research and could withdraw at any time. RESULTS: Respondents with greater work experience more often had a feeling of fatigue and exhaustion after each working day in RIC- (p=0.039). However, respondents with less work experience were significantly colder towards people since they worked in the Covid department or RIC (p=0.006). It was found that subjects with burnout syndrome had a significantly more frequent traumatic experience while working in the Covid center (p=0.049). It was also proven that subjects with burnout syndrome felt tired and exhausted before the working day in RIC (p=0.050). Analyzing the responses of the subjective perception of stress in relation to the function in the RIC, it was found that nurses worried significantly more often because they did not know how much they could trust and rely on colleagues at work during the COVID-19 pandemic because they were not sure of their knowledge and abilities (p=0.005). Doctors significantly more often could not relax and not think about work after finishing work in the RIC (p=0.021). CONCLUSION: From the obtained data of this research, we can conclude that the length of work in the respiratory center did not affect the development of burnout syndrome. The hypothesis was that the female gender had a higher level of stress and burnout syndrome but both sexes have the same probability of developing burnout syndrome. Respondents who developed burnout syndrome were more often exposed to stressful events in the respiratory center. The research proved that doctors had significantly higher burnout syndrome than nurses/technicians