Aim: The objective of this research is to analyze bacterial superinfections in patients suffering from SARS-CoV2 infection in the "fourth wave" treated in the intensive care unit of the Split Clinical Hospital Center. Methods: Data were collected by reviewing the written patient protocol, patient history in the information system (HIS) and microbiological testing data and results. Data were collected and analyzed on the number of hospitalized patients, the number of microbiological examinations, the number of positive microbiological samples for bacterial pathogens, and data of the type of pathogen. Results: A total of 3,764 microbiological samples from 500 patients were analyzed for research purposes.In the analysis of microbiological samples of bronchial aspirate, 12 bacterial cases out of a total of 52 were confirmed, and in the analysis of 792 samples of tracheal aspirate, 483 bacterial cases (60.96%) were confirmed. The analysis of microbiological blood samples confirmed 281 (28.24%) cases of bacteria in the blood analysis from the CVC, and 209 (21.46%) in the microbiological analysis of the blood from the periphery. For the purposes of this analysis, 951 urine samples were taken, and it was determined that 87 urine samples were positive for bacterial microorganisms (9.15%). Conclusion: The proportion of bacterial superinfections was most often confirmed in the results of microbiological analysis of tracheal aspirates, and other research on the topic of bacterial superinfections showed that developed and rich countries have a lower rate due to prevention methods and better healthcare. The role of the nurse/technician in preventing VAP, infections of intravascular catheters and urinary catheters has been proven to be unquestionably important in preventing bacterial superinfections in the ICU.