Objective: to compare endoscopic and surgical treatment of VUR in children from the Children's Surgery Clinic of KBC Split from 2017 to 2024. Data sources and methods: 206 children from the Children's Surgery Clinic of KBC Split who were treated between 2017 and 2024 participated in the research, of which 151 children were treated with the endoscopic method, and 55 children with one of the methods of open surgical treatment. The collected data were processed using the statistical software STATISTICA 13. Numerical variables were presented using the methods of descriptive statistics, while the normality of the distribution was previously tested with the Kolmogorov-Smirnov test. Both the Chi-square test and Fisher's exact test were used, while numerical variables were compared using the Mann-Whitney U test. Results: The research showed a statistically significant difference in the representation of endoscopic and surgical treatment, in the duration of hospitalization and the use of analgesics, and a statistically significant association between attempts at endoscopic treatment of VUR and performed surgical treatment in the examined sample. It was also proven that there is a statistically significant association between a higher degree of VUR and surgical treatment in the examined children and a statistically significant difference between extravesical and intravesical methods of open surgical treatment in the examined children. No statistically significant difference was observed depending on the treatment modality of VUR in the examined children with regard to gender. Conclusion: Endoscopic treatment of VUR in pediatric patients has an advantage over open surgical treatment bacause is less invasive and due to shorter hospitalization and less use of analgesics. However, endoscopic treatment is not always successful, especially when it comes to higher degrees of VUR. In the treatment of patients with VUR, the role of the nurse/medical technician is particularly important in order to effectively provide health care should know how to communicate and supportchild and his parents, educate parents about the importance of proper nutrition after the child's discharge from the hospital and efficiently perform other nursing tasks in the pre-operative period, during operation and after it.