Intrahospital or nosocomial infections are infections that occur during the patient's stay in a health institution in the period from 48 to 72 hours after hospitalization, depending on the incubation of a certain infection. They represent a serious problem in the world, both health and financial. Despite medical progress, and great efforts in prevention, these infections cause significant morbidity, mortality and prolongation of the patient's stay, which results in a burden on the health system. They appear independently of the primary disease, and the problem of antibiotic resistance further complicates the situation. Hospital infections arise as a result of poor quality maintenance of hygiene in health-care facilities, and raise concerns among health personnel and the population itself about the increasing incidence, particularly in intensive care units. Hospital infection rates reflect the quality of health care. In intensive care units, patients are more susceptible to infections, especially due to immunocompromise, which can lead to complications and thus a more demanding recovery. The most common intrahospital infection in the ICU is urinary tract infections. Among other things, the challenge in the work for nurses/technicians is represented by ventilator-associated pneumonia (VAP), as well as sepsis infections and surgical wound infections. It is important to have a quality infection control system to prevent and control intrahospital infections and to ensure patient safety and provide quality health care. Strict adherence to hygiene protocols, proper use of antibiotics, regular cleaning and disinfection of spaces and equipment, and education of medical staff and patients on prevention measures are key to reducing the incidence of hospital-acquired infections.