Nervus radialis is a mixed nerve that arises from the posterior bundle of the manual plexus. It sensibly innervates the skin of the back of the upper arm and forearm, the back of the hand and partially the skin of the fingers. The main motor functions are extension of the forearm, wrist and fingers, extension and abduction of the thumb, supination of the forearm, and flexion of the forearm in a position between supination and pronation. As a result of nerve damage, depending on the location of the injury, numbness of all the muscles it innervates may occur, or branches for individual muscles may be spared. Most often is manifested by a hanging fist. The damage is most often at the level of the spiral groove of the humerus, and less often at the level of the supinator m. Treatment depends on the cause, localization and degree of damage, and can be conservative or surgical. In addition to appropriate and precise diagnostics, a professional plan and program of rehabilitation of the patient is needed, which must be individually adapted to the patient. Physiotherapy interventions as part of rehabilitation include kinesitherapy, thermotherapy, electrotherapy, biofeedback, magnetotherapy, hydrotherapy, laser, occupational therapy, massage, acupuncture, application of orthoses. Physiotherapy interventions improve joint range of motion, muscle strength and flexibility, reduce pain, prevent or correct contractures, and accelerate nerve recovery. The effectiveness of physiotherapy procedures has been proven in numerous studies, but further research comparing different physiotherapy interventions is needed.