Objectives The aim of this study is to analyze the epidemiological characteristics of epidemic meningitis in the Split-Dalmatia County in the twenty - year period from 1995 to 2014. Methods In this paper were observed the important epidemiological features of invasive meningococcal diseases through the retrospective analysis of the patients. Patients are classified according to the time of infection, age and sex. Laboratory findings, disease manifestations, incidence of illness and treatment outcome were analyzed. The data on infectious diseases/deaths of the Department of Epidemiology of Infectious Diseases of the Institute of Public Health of the Split-Dalmatia County were used, among which are data from the book of reception and hospitalization of the Clinical Center for Infectious Diseases of KBC Split. Results In the observed period, the total number of people affected was 138, of which 76 (55%) men and 62 (45%) of women, making an average of incidence of 1.49/100.000 inhabitants. Six patients died and lethality was 4.35%. More than half of the patients (50.72%) are in the age group 0-4 years. Meningococcal disease was the most commonly induced N. meningitidis seroscopic B. Clinically manifested as sepsis in 51 (36.96%) patients, then as meningitis and sepsis 47 (34.06%) and meningitis in 40 (28.99%) patients. The disease is most common in colder month, in February 23 (16.67%), in January 20 (14.49%) and April 20 (14.49%). Conclusion Meningococcal disease is still public health problem. In the underdeveloped countries it appears endemic, while in the developed it usually occurs sporadically. Mortality from invasive meningococcal disease worldwide is 10-15%. Early detection of the symptoms of meningococcal disease is very important. It is obligatory to report, isolate and treat the patients. For the purpose of prevention of secondary cases, it is necessary to conduct chemoprophylaxis of the closest contacts. The best protection against meningococcal disease is recommended immunization and general hygiene measures.