Title Učestalost i značaj citološke dijagnoze limfocitni tip pleuralnog izljeva Title (english) FREQUENCY AND SIGNIFICANCE OF CYTOLOGICAL DIAGNOSIS OF LYMPHOCYTIC TYPE OF PLEURAL EFFUSION Author Elena Tomić Mentor Renata Beljan Perak (mentor) Committee member Daniela Šupe-Domić (predsjednik povjerenstva)Committee member Dinka Šundov (član povjerenstva)Committee member Renata Beljan Perak (član povjerenstva) Granter University of Split Defense date and country 2022-07-01, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Cilj rada: Ciljevi ovoga rada bili su odrediti udio limfocitnog tipa izljeva (LPI) u ukupnome broju pleuralnih izljeva (PI), udio citološki dijagnosticiranih malignih bolesti u ukupnome broju LPI te odrediti raspodjelu LPI prema dobi, spolu i kliničkoj dijagnozi.
Mateijali i metode: U istraživanje je uključeno 116 uzoraka PI analiziranih na Odjelu za kliničku citologiji KBC Split od 1.siječnja do 31.prosinca 2021 godine. Od tog broja bilo je 69 uzoraka s dijagnozom LPI koji su dalje statistički obrađivani.
Klinički podatci dobiveni su iz arhive medicinske dokumentacije.
Uzorkovanje PI izvršeno je na Odjelu za pulmlogiju KBC Split, a uzorci su analizirani po standardnim citomorfološkim kriterijima na Odjelu za kliničku citologiju, KBC Split.
Rezultati: Od 116 uzoraka PI bilo je 69 LPI (59,5%). Prosječna dob pacijenata bila je 72 godine ( SD=11,247). Raspodjela LPI prema spolu bila je otprilike jednaka, muškaraca (53,6%) i žena (46,4%).
7 (10,2%) pacijenata je imalo prethodno dijagnosticiran Covid-19. Od toga su 4 pacijenta ( 5,8%) uz Covid-19 imali i malignu dijagnozu u anamnezi, a 3 pacijenta (34,35%) su bili bez maligne dijagnoze.
Od ostalih dijagnoza iz povijesti bolesti najčešće su bile kardiovaskularne bolesti ( 20,6%), benigne novotvorine (17,5%) i respiratorne bolesti ( 12,2%).
Zaključak: Citologija ima značajnu ulogu u dijagnostici uzroka pleuralnih izljeva. Citološkom analizom može se postaviti definitivna dijagnoza na brz, jednostavan i visoko specifičan način. Kod malignih izljeva može utvrditi porijeklo malignih stanica i tako odrediti osnovu bolest. Utvrđeno je da su kardiovaskularne bolesti najčešći ne maligni uzrok kako PI, tako i LPI. Covid-19 je nova bolest i stoga nema puno istraživanja o povezanosti Covida-19, pleuralnih izljeva i malignih bolesti. U ovome istraživanju 10,2% ispitanih pacijenata imalo je Covid-19. 5,8% pacijenata imalo je i malignu dijagnozu u anamnezi. Potrebna su daljnja istraživanja da bi se utvrdila moguća povezanost Covida-19 i pleuralnih izljeva.
Abstract (english) Research objective: The objectives of this research were to determine the proportion of lymphocyte-type effusions (LPI) in total pleural effusions (PI), the proportion of cytologically diagnosed malignancies in total LPI and to determine the distribution of LPI by age, sex and clinical diagnosis.
Materials and methods: The study included 116 PI samples analyzed at the Department of Clinical Cytology, University Hospital Center Split from January 1 to December 31, 2021. Of that number, there were 69 samples with a diagnosis of LPI that were further statistically processed.
Clinical data were obtained from the archives of medical records.
PI sampling was performed at the Department of Pulmonology, University Hospital Center Split, and samples were analyzed according to standard cytomorphological criteria at the Department of Clinical Cytology, University Hospital Center Split.
Results: Of the 116 PI samples, 69 were LPI (59.5%). The average age of the patients was 72 years (SD = 11,247). The distribution of LPI by gender was approximately equal, men (53.6%) and women (46.4%).
7 (10.2%) patients had previously been diagnosed with Covid-19. Of these, 4 patients (5.8%) had a history of malignant diagnosis in addition to Covid-19, and 3 patients (34.35%) had no malignant diagnosis.
Of the other diagnoses in the history of the disease, the most common were cardiovascular diseases (20.6%), benign neoplasms (17.5%) and respiratory diseases (12.2%).
Conclusion: Cytology plays a significant role in diagnosing the causes of pleural effusions. Cytological analysis can make a definitive diagnosis in a quick, simple, and highly specific way. In malignant effusions, it can determine the origin of malignant cells and thus determine the basis of the disease. Cardiovascular disease has been found to be the most common non-malignant cause of both PI and LPI. Covid-19 is a new disease and therefore there is not much research on the association of Covid-19, pleural effusions and malignancies. In this study, 10.2% of the patients examined had Covid-19. 5.8% of patients also had a history of malignancy. Further research is needed to determine the possible association of Covida-19 and pleural effusions.
Keywords
Pleuralni izljev
limfociti
Covid-19
citologija
Keywords (english)
Pleural effusion
lymphocytes
Covid-19
cytology
Language croatian URN:NBN urn:nbn:hr:176:872433 Study programme Title: Medical Laboratory Diagnostics (university/undergraduate) Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2022-07-05 09:29:19
