Objective: To examine the quality of life (QOL) in patients with laryngeal cancer after total laryngectomy (TL) with unilateral or bilateral neck dissection and to determine the difference depending on the treatment modality (TL with unilateral or bilateral neck dissection ± adjuvant radiotherapy or chemoradiotherapy). Subjects and methods: A cross-sectional study including 30 patients after TL with unilateral or bilateral neck dissection treated at University hospital of Split in the period from 1st of January 2019. to 31st of December 2021. Patients were interviewed using standardized questionnaires on demographic data, quality of life and swallowing status (The University of Washington Quality of Life Questionnaire - UW-QOL and M.D. Anderson Dysphagia Inventory - MDADI). Results: The study included 30 patients with a median age of 67 (min-max: 51-75) years, of which 90% were men. More than 80% of patients had lower education and 60% of patients were in an (extra)marital union. Depending on the treatment modality, the subjects were divided into two groups: in the first group (N = 9) there were patients in whom only TL with unilateral or bilateral neck dissection was performed, while in the second group (N = 21) there were patients in whom adjuvant oncological treatment (radiotherapy or chemoradiotherapy) was performed after TL with unilateral or bilateral neck dissection. In both groups, patients reported a high quality of life (UW-QOL), median 925 vs 950, and satisfactory swallowing ability (MDADI), median 92 vs 84.5. There was no statistically significant difference in the examined variables (all p> 0.05). Post-hoc analysis showed that swallowing (p = 0.023) and chewing (p = 0.048) were less impaired in group 1. As the most important subjective item after treatment, patients in both groups reported speech (all p <0.05). Conclusion: Patients with laryngeal cancer have a subjectively high quality of life regardless of treatment modality. Multidisciplinary care is needed for all potential therapeutic limiting and mutilating treatment outcomes, especially speech.