Objective: Course of vaccine administration against the COVID-19 disease in Split-Dalmatia County in the observed period from 27.12.2020. until 23.3.2023. Methods: Collected data are presented using descriptive epidemiological variables: vaccinated per week, administered doses, vaccination providers and residency. The data were collected from the available databases of the Croatian Institute of Public Health and the Teaching Institute of Public Health of Split-Dalmatian County and analyzed using Microsoft Excel software application. Results: Vaccination against the SARS CoV-2 virus proved to be one of the most important public health measures in protecting the health of the individual as well as the population. According to the data of the Croatian Institute of Public Health, 59.95% of the total population in the Republic of Croatia has been vaccinated. By the end of February 2023, out of the total distributed vaccine in Croatia, 77.3% was administrated. The largest vaccine intake was during the pandemic waves in 2021 and 2022, later the citizens' interest in receiving the vaccine dropped significantly. The higest vaccine coverage in the Split-Dalmatian County was noted on the islands, then on the coast, while mainland had the lowest rate. Overall, according to the total number of inhabitants, 40.83% of the population in the Split-Dalmatian County were vaccinated with primary vaccine series. The most inhabitants of the County received the Comirnaty vaccine, and the least number were immunized with Nuvaxovid vaccine. According to observed age groups, the percentages of vaccinated based on total population of Croatia, were different. The most of vaccinated people belonged to the age group 70-79 years. Children and the youth had the lowest vaccination rates. Conclusions: Vaccination against SARS CoV-2 remains the most effective tool for prevention of more severe clinical forms of the disease, hospitalization and death from COVID-19. Immunization is especially important for the elderly, with susceptible chronic diseases, as well as immunocompromised people. Since vaccination protection decreases over time, continuous vaccination of at-risk population groups is necessary. Clear and targeted guidelines are intended for the reduction of fatigue and information overload about vaccination against COVID-19 in the public. In order to achieve wider vaccination coverage, it is necessary to develop existing health resources, based on previous experiences. The continuous work of all healthcare workers, with the participation of the media, as well as the society, in education and promoting of immunization can increase citizens' interest in vaccination against the SARS CoV-2 virus.