Wegener's granulomatosis (granulomatosis with polyangiitis, GPA) is a rare autoimmune systemic disease that affects small blood vessels and forms necrotizing granulomas, which can result in severe organ damage such as to the lungs, kidneys, and airways. This thesis presents a case of a 27-year-old male who was hospitalized in May 2023 in the Intensive Care Unit of KBC Split. The nursing care of patients with GPA requires a multidisciplinary approach to effectively manage symptoms and complications. A multidisciplinary approach to a patient with Wegener's granulomatosis involves various branches of medicine as well as collaboration between ICU nurses and other nurses. Key aspects of nursing care for patients with GPA include the administration of immunosuppressive therapy, management of complications such as infections and bleeding, and improving patients' quality of life through education about the disease and support in rehabilitation. Teamwork among medical professionals, including anesthesiologists-intensivists, rheumatologists, pulmonologists, nephrologists, and nurses, is crucial for providing comprehensive care and improving the prognosis of patients with Wegener's granulomatosis. Nurses are essential in the care of patients with GPA. Through continuous patient education, infection prevention, and the application of therapeutic procedures, nurses play a key role in improving the quality of life for these patients.