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master's thesis
Adaptivna radioterapija raka prostate - pregledni rad
2024. urn:nbn:hr:176:517641
Han, Marina
University of Split
University Department of Health Studies

Cite this document

Han, M. (2024). Adaptivna radioterapija raka prostate - pregledni rad (Master's thesis). Split: University of Split. Retrieved from https://urn.nsk.hr/urn:nbn:hr:176:517641

Han, Marina. "Adaptivna radioterapija raka prostate - pregledni rad." Master's thesis, University of Split, 2024. https://urn.nsk.hr/urn:nbn:hr:176:517641

Han, Marina. "Adaptivna radioterapija raka prostate - pregledni rad." Master's thesis, University of Split, 2024. https://urn.nsk.hr/urn:nbn:hr:176:517641

Han, M. (2024). 'Adaptivna radioterapija raka prostate - pregledni rad', Master's thesis, University of Split, accessed 10 December 2024, https://urn.nsk.hr/urn:nbn:hr:176:517641

Han M. Adaptivna radioterapija raka prostate - pregledni rad [Master's thesis]. Split: University of Split; 2024 [cited 2024 December 10] Available at: https://urn.nsk.hr/urn:nbn:hr:176:517641

M. Han, "Adaptivna radioterapija raka prostate - pregledni rad", Master's thesis, University of Split, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:176:517641

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Metadata
TitleAdaptivna radioterapija raka prostate - pregledni rad
Title (english)Adaptive radiotherapy of prostate cancer - review
AuthorMarina Han
MentorTomislav Omrčen (mentor)
Committee memberFrane Mihanović (predsjednik povjerenstva)
Committee memberDarijo Hrepić (član povjerenstva)
Committee memberTomislav Omrčen (član povjerenstva)
GranterUniversity of Split
(University Department of Health Studies)
Split
Defense date and country2024-11-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Ovaj diplomski rad analizira temu adaptivne radioterapije kao naprednog i inovativnog pristupa u liječenju karcinoma prostate, naglašavajući njezine prednosti u odnosu na konvencionalne tehnike zračenja. Tradicionalne metode radioterapije često ne mogu uzeti u obzir dnevne promjene u anatomiji pacijenta što može rezultirati suboptimalnom isporukom doze te povećanim rizikom od oštećenja zdravih tkiva te organa od rizika. Adaptivna radioterapija rješava ovaj problem omogućujući prilagodbu plana liječenja tijekom svake sesije koristeći napredne tehnike poput multiparametrijske magnetske rezonancije i MR-Linac tehnologije. Primjena adaptivne radioterapije uključuje detaljno konturiranje ciljnog volumena zračenja te organa od rizika na temelju dnevnih snimaka čime se postiže veća preciznost u isporuci doze te se smanjuju neželjeni učinci na okolna zdrava tkiva. U usporedbi s konvencionalnim tehnikama poput 3D konformalnog zračenja ili radioterapijom modularnog intenziteta, adaptivna radioterapija omogućuje bolje praćenje i prilagodbu plana liječenja u stvarnom vremenu što dovodi do značajnih kliničkih poboljšanja. U radu su također razmatrani tehnički aspekti implementacije adaptivne radioterapije uključujući upotrebu naprednih softverskih rješenja za optimizaciju plana i izračuna doze kao i potrebe za dodatnom edukacijom stručnog osoblja. Unatoč tim izazovima rezultati kliničkih studija pokazuju značajno poboljšanje u lokalnoj kontroli bolesti i smanjenju toksičnosti kod pacijenata s karcinomom prostate. Budući razvoj adaptivne radioterapije uključuje integraciju umjetne inteligencije (AI) za automatsku segmentaciju i prilagodbu planova što bi moglo dodatno smanjiti vrijeme tretmana i povećati učinkovitost. Ova tehnologija uz podršku sve naprednijih hardverskih i softverskih rješenja ima potencijal postati standard u liječenju karcinoma prostate i drugih oblika raka pružajući pacijentima individualizirani pristup temeljen na specifičnostima njihove anatomije i biološkog odgovora na terapiju.
Abstract (english)
This thesis analyzes the topic of adaptive radiotherapy as an advanced and innovative approach in the treatment of prostate cancer highlighting its advantages over conventional radiation techniques. Traditional radiotherapy methods often cannot account for daily anatomical changes in the patient which can result in suboptimal dose delivery and an increased risk of damage to healthy tissues and organs at risk. Adaptive radiotherapy addresses this issue by allowing the treatment plan to be adjusted during each session using advanced techniques such as multiparametric magnetic resonance imaging and MR-Linac technology. The application of adaptive radiotherapy includes detailed contouring of the target volume and organs at risk based on daily imaging achieving greater precision in dose delivery and reducing adverse effects on surrounding healthy tissues. Compared to conventional techniques like 3D conformal radiation or intensity-modulated radiotherapy adaptive radiotherapy enables better monitoring and real-time adaptation of the treatment plan leading to significant clinical improvements. The thesis also discusses the technical aspects of implementing adaptive radiotherapy including the use of advanced software solutions for plan optimization and dose calculation as well as the need for additional education for professional staff. Despite these challenges clinical studies show significant improvements in local disease control and reduced toxicity in prostate cancer patients. The future development of adaptive radiotherapy involves the integration of artificial intelligence (AI) for automatic segmentation and plan adaptation which could further reduce treatment time and increase efficiency. This technology supported by increasingly advanced hardware and software solutions has the potential to become the standard in the treatment of prostate cancer and other forms of cancer providing patients with an individualized approach based on their anatomical and biological response to therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:176:517641
Study programmeTitle: Graduate University Study Programme of Radiologic Technology
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra radiološke tehnologije (sveučilišni/a magistar/magistra radiološke tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-12-03 09:02:54