Aim: To explore the perception of the quality of life of multiple sclerosis patients. Establish which factors affects on better perception of the quality of life of multiple sclerosis patients, and establish the most appropriate ways to raise the quality of life. Methods: The research was conducted on the basis of collected data received by a one-time questionnaire by a standard questionnaire of the name MSQOL-54 of the Company of Multiple Sclerosis Society Split during May and June 2017. In the study, 31 respondents participated, 24 of them were women and 7 were man. The age range was 26-81 years old. All surveys were conducted, there was no rescission of the survey. Results: According to research results, it is possible to conclude that respondents evaluate their quality of life very well, meaning that they are generally satisfied with meeting the basic human needs associated with their disadvantage. Most of the respondents are satisfied with their life, despite their illness, and are rated at an average rating of 8/10. Most of the respondents are not satisfied with their physical health and lack of physical strength have difficulties in carrying out the activities they need. As for mental health, we can conclude from the results of research that most respondents have difficulty concentrating and thinking. Conclusion: The results of this study show that respondents evaluate the quality of life satisfactory, and are rated as "very good". People suffering from multiple sclerosis show dissatisfaction with the perception of energy, pain, health anxiety, and cognitive functioning. Respondents regularly control their disease and are well tolerated by therapeutic procedures. The research results obtained are in line with other worldwide research on this topic.