Tomosynthesis is a radiographic method that works on the basis of tomography and allows a layered view of the body without the effect of tissue summation. The X-ray tube moves in arc form above the receptor and the exposure happens every several degrees. Collected raw data is transformed into thin slices using reconstruction algorithms and displayed individually or as ciné loop. Tomosynthesis is used on musculoskeletal system for the detection of microfracture and the presentation of metal implants due to the small amount of metal artifacts, but it is most commonly used in breast diagnosis. In the case of breast tomosynthesis, the breast is compressed, and the x-ray tube moves above it. In order to achieve the best image quality, it is necessary to select the optimum angle of motion, and most often it is between 10° and 20°. In addition to selecting the angle, it is very important to shorten the time of the scan to allow the use of tomosynthesis for the purpose of screening, but also to reduce the patient's discomfort for the sake of breast compression. Estimates have shown that tomosynthesis gives the best diagnostic results when applied in combination with mammography and when tomosynthesis is applied on both standard projections, CC and MLO. Also, research has shown an increased number of detected lesions in all breasts types and that it has the best results in dense breasts, where the need for subsequent treatment of the patients is reduced by 57%, and 70% of the cancer is better or only presented with the help of tomosynthesis. Diagnosis of Invasive Cancer with no microcalcifications is increased by as much as 40-53%. Tomosynthesis can be used as a screening method or as a method for treating symptomatic patients, and in both cases it gives better results in comparison with mammography alone. In cases of limited number of tomosynthesis devices the best way to use them is on patients with dense breasts and as a screening method. The fact is that tomosynthesis is a relatively new method in radiography and that there are still some problems to be addressed, namely the patient dose exposure issues, reading time and the amount of data being saved on the PACS system. Solution for radiation dose reduction is the development of C-view software that reconstructs a two-dimensional image from the data collected by the tomosynthesis. Tomosynthesis is a method that still has room for progress, and the development of CAD systems for tomosynthesis, tomosynthesis guided biopsy and contrast mammography combined with tomosynthesis will provide the best care for patients.