Research objectives: The research was aimed to investigate and compare the quality of life for terminal patients in hospital care compared to patients in the home care, and observe the factors that influence the perception of the quality of life in the terminal stage Methods: For the study we used a one-time survey of terminal and chronic patients in Knin General Hospital and patients in home care. The study included 50 patients. The survey was conducted from March to June 2016. in the way of one-time survey of respondents about the quality of life. For the statistical analysis all data is entered and processed in Microsoft Excel tables. Statistical analysis included the distribution of frequencies. For data analysis was used descriptive statistics. Results: In the category of quality of life according to the daily activities, respondents have substantial and largely agreed that in the past two weeks have significant reductions in activity. Through the category of psychological and physical experience of illness from the survey, results show that respondents in both groups moderate and largely believe that their life has no meaning. Psychophysical abilities respondents rated as significantly and increasingly have less energy than before the onset of disease. As satisfaction with various aspects of life are concerned, respondents in hospital care in greater proportion are satisfied with the medical services, but are less satisfied with their lives and relationships with loved ones. Both groups agree on the answers to be significantly depressed and discouraged about the future and often develop negative feelings. Conclusion: By polling terminal and chronic patients and examining the factors that influence the perception of quality of life, and these are: everyday activities, satisfaction of various aspects of life and emotional experiences, we got the information that we have previously stated in the results. The goal of research is to investigate the quality of life of terminal and chronic patients in hospital care and home care. We conclude that the medical side of the quality of life is better in hospital care (satisfaction with the med. services, treatment improves quality of life), while emotional life is better in home care which is reflected in higher satisfaction of respondents itself and interacting with loved ones.