Depression is a biopsychosocial disorder. It is a significant problem for the patients themselves, but also from the public health point of view.. A large set of symptoms that are reflected substantially disturbs the overall human functioning. It occurs in many clinical forms that determine the way of treatment. Treatment is quite successful and involves a holistic approach. In therapeutic team, that treats patient with depressive disorder, a nurse has a significant role. Her role begins at the time of the patient's admission, and quality of that reception determine a lot, whether confidence and empathy will be developed, and will the nurse manage to create therapeutic atmosphere. Furthermore, the nurse daily carries out the physical and mental health care of the patient, and during it observes, records and transfers to other members of the team data on the patient's behavior and participation in the activities at the department. It's also significant her role in interpersonal relationships. In the first place, in the relationship between herself and the patient. Then, as advocate of patient needs, in the relationship between the patient and the rest of the therapeutic team. In the relationships of patient with other patients, and ultimately in the relationships of patients with his family and friends. Therefore, from a certain perspective, the underlying role of a nurse in a therapeutic team treating depressive patient is to unite all aspects of medical care.