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master's thesis
Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija
2019. urn:nbn:hr:176:626393
Vuletić, Vide
University of Split
University Department of Health Studies

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Vuletić, V. (2019). Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija (Master's thesis). Retrieved from https://urn.nsk.hr/urn:nbn:hr:176:626393

Vuletić, Vide. "Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija." Master's thesis, University of Split, University Department of Health Studies, 2019. https://urn.nsk.hr/urn:nbn:hr:176:626393

Vuletić, Vide. "Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija." Master's thesis, University of Split, University Department of Health Studies, 2019. https://urn.nsk.hr/urn:nbn:hr:176:626393

Vuletić, V. (2019). 'Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija', Master's thesis, University of Split, University Department of Health Studies, accessed 14 March 2023, https://urn.nsk.hr/urn:nbn:hr:176:626393

Vuletić V. Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija [Master's thesis]. Split: University of Split, University Department of Health Studies; 2019 [cited 2023 March 14] Available at: https://urn.nsk.hr/urn:nbn:hr:176:626393

V. Vuletić, "Iskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija", Master's thesis, University of Split, University Department of Health Studies, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:176:626393

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TitleIskustva Klinike za onkologiju i radioterapiju KBC Split u konkomitantnoj kemoradioterapiji raka pluća nemalih stanica 3D konformalnom tehnikom - dozimetrijska studija
Title (english)EXPERIENCES OF THE ONCOLOGY AND RADIOTHERAPY CLINIC IN CONCOMITANT CHEMORADIOTHERAPY OF NON-SMALL CELL LUNG CANCER WITH 3D CONFORMAL TECHNIQUES - DOSIMETRIC STUDY
AuthorVide Vuletić
MentorTihana Boraska Jelavić (mentor)
Committee memberTihana Boraska Jelavić (član povjerenstva)
Committee memberLjubica Žunić (član povjerenstva)
Committee memberDarijo Hrepić (predsjednik povjerenstva)
GranterUniversity of Split
University Department of Health Studies
Split
Defense date and country2019-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
CILJ ISTRAŽIVANJA: Ispitati toksičnost na organe od rizika kod konkomitantne kemoradioterapije kod pacijenata s karcinomom pluća nemalih stanica, ispitati dozimetrijske trendove na organe od rizika te dobivene rezultate prikazati kao trend kroz godine. Ispitati razvoj akutnih toksičnosti te rezultate usporediti sa svjetskom literaturom. PACIJENTI I METODE: Ovo je retrospektivna studija provedena na Klinici za onkologiju i radioterapiju KBC-a Split. Prikupljeni su podaci oboljelih od lokalno uznapredovalog nesitnostaničnog karcinoma pluća liječenih trodimenzionalnom konformalnom kemoradioterapijom od 2011. godine do početka 2019. godine. Prikupljeni su podatci pacijenata koji su se zračili primarno, adjuvantno i/ili neoadjuvantno. Uključeni pacijenti primili su najmanje jedan ciklus kemoterapije. Ciljni volumeni i organi od rizika ocrtani su prema radioterapijskim smjernicama. REZULTATI: Medijan doze na PTV bio je 56 Gy. Najčešća akutna toksičnost bila je hematološka (lekupenija i neutropenija) i radijacijski akutni ezofagitis. Nije zabilježen nijedan slučaj akutnog radijacijskog pneumonitisa. Nije pokazana korelacija između prekoračenja doze na zadane volumene organa od rizika i toksičnosti istih, te smo ukazali na trend poboljšanja dozimetrijskih rezultata kroz godne. ZAKLJUČAK: Toksičnost liječenja 3D konformalnom radioterapijom lokalno uznapredovalog raka pluća u Klinici za onkologiju i radioterapiju KBC-a Split usporediva je s objavljenim rezultatima drugih svjetskih institucija. Medijan doze na planirani volumen je nešto niži od preporučenog u stručnim smjernicama što je odraz realne kliničke prakse i retrospektivnog ustroja istraživanja
Abstract (english)
AIM OF THE STUDY: To research organs at risk toxicity for concomitant chemoradiotherapy in non-small cell lung cancer patients, research dosimetric trends for organs at risk, and present the results as a trend over the years. To research the development of acute toxicities and compare the results with the worldwide literature. SUBJECTS AND METHODS: This is a retrospective study conducted at the Oncology and Radiotherapy Clinic of the Clinical Hospital Center Split. Data were collected from patients with locally advanced non-small cell lung cancer treated with three-dimensional conformal chemoradiotherapy from 2011 to early 2019. Data were collected from patients who were treated with primary, adjuvant, and/or neoadjuvant radiotherapy. The patients involved received at least one cycle of chemotherapy. The target volumes and organs of risk were delineated according to radiotherapy guidelines. RESULTS: The median dose on PTV was 56 Gy. The most common acute toxicity was hematological toxicity (leukopenia and neutropenia) and acute radiation esophagitis. No cases of acute radiation pneumonitis were noted. No correlation has been noted between dose override on organs of risk volumes and toxicity, and we have pointed to a trend of improving dosimetric results through the years. CONCLUSION: The toxicity of treatment with 3D conformal radiotherapy for locally advanced lung cancer at the Oncology and Radiotherapy Clinic of the Clinical Hospital Center Split is comparable to the published results of other worldwide institutions. The median dose for the planned volume is slightly lower than recommended by the professional guidelines, which is reflecting real clinical practice and retrospective research.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:176:626393
Study programmeTitle: Radiologic Technology (university/graduate)
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra radiološke tehnologije (magistar/magistra radiološke tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-06-24 06:49:57