Title Hipofrakcionirano zračenje raka prostate
Title (english) HYPOFRACTIONATED RADIATION THERAPY FOR PROSTATE CANCER
Author Dina Čobo
Mentor Tihana Boraska Jelavić (mentor)
Committee member Maja Marinović Guić (predsjednik povjerenstva)
Committee member Darijo Hrepić (član povjerenstva)
Committee member Tihana Boraska Jelavić (član povjerenstva)
Granter University of Split (University Department of Health Studies) Split
Defense date and country 2020-07-02, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract Rak prostate predstavlja veliki problem današnjice s visokom stopom incidencije. U mnogim zemljama nalazi se među najčešćim karcinomima i uzrocima smrti kod muškaraca. Karcinom prostate je spororastući tumor i u većini slučajeva nema simptoma. Učestalost mu raste s dobi. Upravo zbog visoke incidencije, razvio se program ranog otkrivanja raka prostate uz pomoć vrijednosti specifičnog antigena prostate (PSA). Osim vrijednosti PSA, važan je digitorektalni pregled i biopsija prostate. Kao i kod drugih malignih bolesti, šanse za izlječenjem su veće ako se tumor otkrije na vrijeme. Odabir liječenja prvenstveno ovisi o stupnju proširenosti tumora, općem stanju pacijenta, pratećim bolestima i dostupnim modalitetima liječenja uzimajući u obzir učinkovitost i toksičnost primjenjene terapije. Radioterapija je čest način liječenja lokaliziranog i lokoregionalnog proširenog karcinoma prostate s kurativnim ciljem, a učestalo se koristi i u proširenoj bolesti kao palijativna metoda liječenja. Zbog ubrzanog razvoja tehnologije i radioterapijske tehnike su posljednjih desetljeća značajno napredovale. Zahvaljujući našem boljem razumijevanju radiobiologije tumora prostate, znanju o niskom α/β omjeru i radiorezistentnoj prirodi karcinoma prostate, razvili su se drukčiji pristupi frakcioniranom zračenju. Hipofrakcionirano zračenje i stereotaksijska tjelesna radioterapija novije su metode teleradioterapije. Cilj hipofrakcioniranja je smanjivanje ukupnog vremena liječenja što je važno pacijentu, povećanje doze zračenja po frakciji radi bolje kontrole bolesti i uz održavanje kvalitete života tijekom i nakon liječenja. Prednosti i nedostatci takvog pristupa dokazali su se mnogim istraživanjima. Neke pojedinosti još nisu definirane, ali istraživanja još traju. Novije metode hipofrakcioniranja s protonima i ugljikovim ionima pokazale su još bolje rezultate kontrole bolesti, ali cijena uređaja i tretmana sprječava globalizaciju uporabe.
Abstract (english) Prostate cancer, today, is one of the leading problems with a high incidence rate. It is one of the most common cancers types and causes of death in many countries. Prostate cancer is a slow growing tumor and in most cases there are no symptoms. It is discovered only with an autopsy in a large percentage of male population. It is less common in the younger population and its frequency increases with age. Because of the high incidence, a program for early detection of prostate cancer was developed with the help of prostate specific antigen (PSA). In addition to PSA values, digitorectal examination and biopsy are also very important. As with other malignancies, the chances of a cure are higher when the tumor is detected in time. The choice of treatment primarily depends on the degree of tumor spread, the general condition of the patient, concomitant diseases and available treatment modalities considering the effectiveness and toxicity of the applied therapy. Radiotherapy is a common way to treat localized and locoregional enlarged prostate cancer with a curative goal, and is also often used in advanced disease as a palliative method of treatment. Due to the rapid development of technology and radiotherapy techniques, they have made significant progress in recent decades. Thanks to our better understanding of the radiobiology of prostate tumors, knowledge of the low α / β ratio, and the radioresistant nature of prostate cancer, different approaches to fractional radiation have been developed. Hypofractionated radiation and stereotactic body radiotherapy are newer methods of teleradiotherapy. The goal of hypofractionation is to reduce the total treatment time (which is very important to the patient), to increase the radiation dose per fraction in order to better control the disease and maintain quality of life during and after treatment. The advantages and disadvantages of such an approach have been proven by many studies. Some details have not yet been defined, but research is still ongoing. Newer methods of hypofractionation with protons and carbon ions have shown even better disease control results, but the cost of devices and treatments prevents the globalization of it’s use.
Keywords
karcinom prostate
radioterapija
hipofrakcioniranje
radiobiologija
kvaliteta života
istraživanje
Keywords (english)
prostate cancer
radiotherapy
hypofractionation
radiobiology
quality of life
research
Language croatian
URN:NBN urn:nbn:hr:176:373084
Study programme Title: Radiologic Technology (university/undergraduate) Study programme type: university Study level: undergraduate Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) radiološke tehnologije (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) radiološke tehnologije)
Type of resource Text
File origin Born digital
Access conditions Open access
Terms of use
Created on 2020-07-13 13:02:12