Duchenne muscle distrophy is a severe and progressive disease which destroys children muscles. Incidence of disease is one in three to five tousand children . It is considered as one of the most common deadly genetic diseases in children. The disease is caused by altering the dystrophin gene on the X chromosome. Such mutations result in the gradual replacement of muscle by adipose and fibrous connective tissue. Approximately one in three cases the disease is caused by a spontaneous mutation. Children diagnosed with Duchenne muscular dystrophy are usually expected to have a wheelchair before puberty. The aim of this study was to compare disease progression and changes that occur with the development of the disease itself in children. The most striking change observed is the weakening of motor functions resulting from muscle deterioration and the replacement of muscle tissue by adipose and fibrous connective tissue. In addition to changes in the muscles, changes in the joints and spine were also observed. Also, as additional side effects of disease progression, we have lung and heart problems in which children often require respiratory support by mechanical ventilation. The most effective treatment for curing children with Duchenne muscular dystrophy is considered to be physical therapy treatment. Children suffering from this disease use glucocorticoids in their treatment and because of their consumption they often suffer from osteoporosis. The gold standard in the treatment of this disease is the timely prevention and treatment of early indications. Also early prevention of contractures and fractures in sick children. The research revealed the exceptional benefit of physical therapy in the treatment and rehabilitation of children, but also in improving their affirmation in society.