Neuromuscular diseases are inherited progressive diseases caused by problems on motoneurons. They manifest at different periods of life where some diseases begin as early as birth, some in early childhood, and some only in adolescence or adulthood. Neuromuscular diseases include numerous diseases and syndromes, each of which has specific symptoms and therapies. Duchenne muscular dystrophy and Charcot-Marie-Tooth disease are highlighted in this paper. Duchenne muscular dystrophy is characterized by proximal muscle weakness and pseudohypertrophy of the lower legs, as well as a positive Gowers sign, pronounced lordosis and limping gait. The symptoms of this disease ultimately lead to immobility. Charcot-Marie-Tooth disease has been described as a syndrome that affects the distal muscles with the development of muscle weakness and atrophy, and is divided into several types with different mode of inheritance and characteristics. The paper also presents research on physical therapy methods for these two diseases, which showed the effectiveness of respiratory muscle training in Duchenne muscular dystrophy, and training with a continuous increase in resistance in Charcot-Marie-Tooth disease. Despite the research presented, future research on these diseases is extremely important.