Objective: To examine and determine the presence of difficulties and quality of life of patients with chronic leukemia regarding gender, marital status and age of the patient. Study design: Cross-sectional study. Subjects and methods: For the purposes of the research, a survey questionnaire was conducted among 44 patients who are members of the Association of Leukemia and Lymphoma in Split in the period from 06/15/2021. to 08/14/2021. Respondents were interviewed through a written questionnaire, rounding off one of the offered answers. Results: 44 respondents participated in the study, of which 58.82% were men and 41.18% women. For most respondents, there is a statistically significant association in the presence of difficulties and quality of life with respect to age. Conclusion: Hypothesis H1, which assumes that there is a statistically significant difference in the presence of difficulties and quality of life with regard to the sex of patients, is accepted as true for the presence of difficulties. Hypothesis H2 which assumes that there is a statistically significant difference in the presence of difficulties and quality of life with regard to marital status is rejected as untrue and H3 which assumes that there is a statistically significant relationship in the presence of difficulties and quality of life with age is accepted as true for the presence difficulty.