Pain is an uncomfortable sensory and emotional experience that occurs regularly in many chronic conditions. In this paper, the use of epidural analgesia in patients with chronic pain is described, of which the use in non-malignant and malignant pain is discussed. Chronic pain is a complex clinical problem that affects all areas of an individual’s life and work. Chronic pain is pain that lasts from 3 to 6 months and longer and remains present even after the tissue healing process has been completed. The use of epidural analgesia in the treatment of low back pain as the most common chronic non-malignant pain is described, and then the use of epidural analgesia in the treatment of carcinoma pain as malignant pain is described. Epidural analgesia is the neuroaxial blockade in which the anesthetic is applied to the epidural space, and its definition, as well as contraindications and complications of the mentioned analgesia, will be given in the paper. Chronic non-malignant pain is treated by giving epidural injections, which usually contain corticosteroids and sometimes local anesthetics, while chronic malignant pain is usually treated by placing a tunneled epidural catheter through which opiates and local anesthetics are given. In the application of epidural analgesia in the treatment of chronic non-malignant and malignant pain, the role of the nurse is of immense importance. The nurse is in charge of conducting quality psychological and physical preparation of the patient, taking detailed anamnesis, educating patients and families about the procedure, preparing aseptic conditions and monitoring the patient during and after the procedure.