The aim of this study was to investigate infertility occurring in couples, as the most common cause of this growing medical problem involving both partners. The research was conducted for the period from January 2021 to December 2021. The results included the age of the patients, the chosen treatment procedure and the outcome of the treatment itself. There are many causes of infertility, which can include hormonal disorders, problems with the testicles or ovaries, problems with the fallopian tubes or endometrium, and many others. One of the methods of treating infertility is artificial reproductive techniques (ART), which includes various techniques to assist in conception. Types of ART include intrauterine insemination (IUI), in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI). The aim of the work was to investigate which medical methods that help fertilization are used the most and have the highest success rate of conception and delivery of a live-born children in the Clinic for Women's Diseases and Childbirth. The methods used were IUI, IVF/ET (embriotransfer), ICSI/ET, FET (frozen embryo transfer). The success rate of all fertilization methods varies depending on various factors, such as women’s age, quality of eggs and sperm, type of fertilization method. In the Clinic for Women's Diseases and Childbirth in Split, the largest number of patients were in the age group under 34 years old, and the smallest number were over 40 years old. In patients over 40 years of age, ICSI treatment has shown the greatest success. The choice of technique depends on the cause of infertility and other factors. It's important to talk to your doctor about your treatment options and expectations before deciding on a fertility treatment method. The research also confirmed that the results of the Institute for Human Reproduction and Endocrinology of the Clinic for Women's Diseases and Childbirth in Split were compared with the results of other developed countries.