Objectives: The main aim of this study was to analyze and compare the values of inflammatory markers (leukocyte count, highly sensitive C-reactive protein, erythrocyte sedimentation rate, ferritin and fecal calprotectin) in patients with inflammatory bowel disease (IBD). Subjects and methods: The study included 40 patients diagnosed with IBD, as well as 40 control participants. Patients with IBD are assigned into subgroups given the subtype of the disease and the type of therapy they receive. All data of the respondents were downloaded from the hospital information system and statistically processed using the MedCalc computer program. Statistical processing of laboratory parameters and basic anthropometric and clinical characteristics of the subjects was made. Results: The results of this study showed that there was no statistically significant difference in anthropometric characteristics of patients with IBD and control group, except in body height (175.0 (171.0-183.0) vs. 181.5 (173.0-190.5); p=0.024). Increased consumption of alcohol (p=0.002) and coffee (p=0.004) was observed in the control participants. For measured inflammatory markers, a statistically significant difference in ferritin levels was observed (39.5 (18.0-72.5) vs. 86.5 (32.5-132.0); p=0.019), while for other measured inflammatory markers there was no statistically significant difference between IBD patients and the control group. The analysis of the data showed no statistically significant difference in anthropometric characteristics with respect to the subtype of the disease. In subjects suffering from Crohn's disease (CD), extraintestinal manifestations (4 (20.0%) vs. 12 (60.0%); p=0.011) were significantly more common, and also in CD patients, increased tobacco consumption (p=0.018) was observed, as opposed to patients with ulcerative colitis (UC). Furthermore, there was no statistically significant difference in the levels of inflammatory markers studied with regard to the subtype of the disease and the type of therapy these patients receive. Conclusion: Inflammatory bowel disease is characterized by a chronic inflammatory process of the gastrointestinal tract. Although there is an inflammatory reaction in the body, this study did not show elevated values of inflammatory markers in patients with IBD. Laboratory parameters are a non-specific indicator of inflammatory bowel disease, but they should be taken into account when diagnosing and assessing the activity of the disease and should be interpreted together with the clinical picture of the patient and the results of other diagnostic procedures.