Objective: The aim of the research is to examine the quality of life of patients suffering from MS, determine the factors that influence the quality of life of patients, and to what extent these factors impact the quality of life of MS patients. Data sources and methods: 70 respondents participated in the survey. Respondents filled out a file with instructions and the MS QoL-54 scale created specifically for the needs of the thesis. The research was conducted using a survey questionnaire and the MS QoL-54 scale to assess the quality of life of those suffering from multiple sclerosis. The MS QoL-54 scale consists of the SF-36 questionnaire and 18 additional questions specific to the symptoms of multiple sclerosis. The collected data was analyzed using descriptive and inferential statistical methods in a statistical program. Measures of central tendency, dispersion, and Spearman’s rank correlation coefficient were used to describe the data. The Kolmogorov-Smirnov test, chi-square test, Student’s t-test, and analysis of variance were used to test the statistical significance of differences. Results: Research on the quality of life of patients with multiple sclerosis showed that there are differences in the assessment of quality of life with regard to age, education and place of residence, but not with regard to gender. People with a more severe form of the disease and more pronounced side effects of the therapy rate their own quality of life as lower. A higher level of social support is associated with a higher assessment of quality of life, and the presence of pain/discomfort and mood changes (depression/anxiety) is associated with a lower assessment of quality of life. Conclusion: Based on the obtained results, it can be concluded that interventions aimed at improving the quality of life of patients with multiple sclerosis should be focused on alleviating the symptoms of the disease such as pain, fatigue and mood changes; minimizing the side effects of pharmacological therapies; ensuring adequate social support from the environment and education about adaptive strategies for coping with the diagnosis. Considering the aim of the research, we can conclude that the mentioned factors significantly moderate the satisfaction with life and the feeling of well-being in patients with multiple sclerosis.