Goal: To define the characteristics of personality and the degree of empathy of the first year students of heath study and to research the contribution of personality characteristics on the prediction of empathy. Metods: 59 students of all five study courses of the Health study department of the university of Split participated in the research. During the lecture of Communication skills the following measuring instruments were used: E-questionnaire for the analysis of empathy and BFQ questionnaire for the analysis of five characteristics of personality (extraversion, agreeableness, conscientiousness, emotional stability and openness) together with the instruction on how to solve the tests, and a note containing the information that the identity of the subject will be known only by the researcher after an informed consent of the subject. Results: The level of empathy of health study students measured by an E-questionnaire has had an average grade of 2.9 on the scale from 0 to 4, which indicates a high level of the empathy of subjects. The personality characteristics measured by BFQ questionnaire in this research are: extraversion, agreeableness, conscientiousness, emotional stability and openness. Emotional stability is located on the lowest level of the scale-2.99 and conscientiousness is located on the highest level of the scale-3,42 (on the scale from 1 to 5). Extraversion, agreeableness and openness have the following average values: extraversion and agreeableness 3,35, and openness 3,32, which indicates a high level of personality characteristics of subjects. Regressive analysis has shown a statistically important connection between three out of five analyzed characteristics of personality- extraversion,agreeableness and conscientiousness, with the negative influence of extraversion on the empathy, and the positive influence of agreeableness and conscientiousness. Conclusion: The existence and the level of empathy as one of the most important and desirable characteristics of health professionals is predictable on the basis of the analysis of personality characteristics of subjects. Extrovers are less emphatical , while conscientious and pleasant people show a high degree of empathy. The influence of emotional stability and openness on the empathy hasn't been recorded.