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undergraduate thesis
Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA
2017. urn:nbn:hr:176:772475
Žunić, Leo
University of Split
University Department of Health Studies

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Žunić, L. (2017). Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA (Undergraduate thesis). Split: University of Split, University Department of Health Studies. Retrieved from https://urn.nsk.hr/urn:nbn:hr:176:772475

Žunić, Leo. "Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA." Undergraduate thesis, University of Split, University Department of Health Studies, 2017. https://urn.nsk.hr/urn:nbn:hr:176:772475

Žunić, Leo. "Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA." Undergraduate thesis, University of Split, University Department of Health Studies, 2017. https://urn.nsk.hr/urn:nbn:hr:176:772475

Žunić, L. (2017). 'Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA', Undergraduate thesis, University of Split, University Department of Health Studies, accessed 07 June 2023, https://urn.nsk.hr/urn:nbn:hr:176:772475

Žunić L. Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA [Undergraduate thesis]. Split: University of Split, University Department of Health Studies; 2017 [cited 2023 June 07] Available at: https://urn.nsk.hr/urn:nbn:hr:176:772475

L. Žunić, "Važnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA", Undergraduate thesis, University of Split, University Department of Health Studies, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:176:772475

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Metadata
TitleVažnost sudjelovanja u timskom radu prvostupnika sestrinstva kod određivanja antigena i gena sustava HLA
Title (english)THE IMPORTANCE OF THE BACHELOR OF NURSING PARTICIPATION IN DETERMINING ANTIGEN AND GLA SYSTEM OF HLA
AuthorLeo Žunić
MentorEsma Čečuk-Jeličić (mentor)
Committee memberIvana Franić (predsjednik povjerenstva)
Committee memberVesna Antičević (član povjerenstva)
Committee memberEsma Čečuk-Jeličić (član povjerenstva)
GranterUniversity of Split
University Department of Health Studies
Split
Defense date and country2017-07-03, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Uvod: HLA sustav je otkriven sredinom 20-og stoljeća. Antigeni ili molekule HLA imaju glavnu ulogu u zadaći imunološkog sustava kod razlikovanja vlastitog od tuđeg zbog pokretanja imunološkog odgovora na tuđe antigene i održavanja integriteta vlastitog organizma. Ključna funkcija gena HLA očituje se u imunološkoj reakciji i u transplantacijskom kliničkom procesu kroz funkciju njihovih najvažnijih produkata - molekula HLA. One su glavni dio antigen-predočnog kompleksa na površini stanica te imaju funkciju predočavanja vlastitih i stranih peptidnih dijelova citotoksičnim i pomoćničkim T-limfocitima. Cilj: Cilj ovog rada je bio prikazati osnovno značenje i funkciju sustava HLA te odgovornost prvostupnika sestrinstva u obavljanju poslova vezanih za dijagnostiku ovog područja. Materijali i metode: Metode koje se koriste za određivanje antigena i alela sustava HLA su: serološka metoda (test mikrolimfocitotoksičnosti) te metode molekularne biologije: PCR-SSP i PCR-SSO. Rezultati i rasprava: Otkrivanjem sustava HLA transplantacija KMS izbor je u liječenju mnogih hematoloških bolesti. Razvojem metoda određivanja gena i antigena sustava HLA povećana je uspješnost transplantacija krvotvornih matičnih stanica. Usavršavanje metoda molekularne biologije donosi i nove spoznaje o još većoj složenosti sustava HLA.
Abstract (english)
Introduction: HLA system was discovered by the middle of the 20th century. Antigens or HLA (Human Leukocyte Antigens) molecules have as their primary role to identify foreign from own molecules in order to initiate an immune response to foreign antigens and to maintain integrity of its own organism. Key function of the HLA genes is in the immune response and the transplant clinical process through the function of its most significant products - HLA molecules. They are the main part of the antigen presentasome complex on the surface of the cells and have as their function to show its own as well as foreign peptide units to cytotoxic and helper T-cells. Scope: the scope of this thesis was to demonstrate the basic significance and function of the HLA system and the responsibility of bachelors of nursing in performing tasks pertaining to diagnostics in this area. Methodology: methods used to determine antigens and alleles of the HLA system are: serological method (microlymphocitotoxicity test) and methods of molecular biology: PCR-SSP and PCR -SSO. Results and discussion: Since the HLA transplant system was discovered it has become the go to choice for treatment of many hematological diseases. The development of methods to determine genes and antigens of the HLA system has increased the success rate of transplanting blood forming stem cells. The improvement of methodology in molecular biology brings forward new insight into greater complexity of the HLA system.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:176:772475
Study programmeTitle: Nursing (university/undergraduate)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) sestrinstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-08-04 12:06:04