Aim: The purpose of this study is to identify the presence of symptoms and signs of autism and set nursing diagnosis for autistic people. Materialandmethods: A study was conducted proteges “Center for Autism” in May 2014 in Split using a questionnaire developed in collaboration with the mentor with 45 symptoms and signs of autism were offered. The questionnarie was completed by the nurses who care for protégée of center. The collected data were recorded using MS Office programs. Data were analyzed and displayed using MS Excel. Results: The conducted study included 30 people. Their average age was 15 (10-31). 17 patients have a reduced interest in imaginative and creative games, 16 patients only eat certain types of food. 14 patients frequently repeat body movements, have angry outbursts, don`t talk / or repeat words. In none of the patients was recorded odd pronunciation of words or expressive talent in sculpture. In one of the patients it was noticed choosing food by color, not by type, talent in mathematics, tendency to hurt himself during playing games, using meaningless rhymes and avoiding physical contact. Conclusion: Major role in treatment of autistic people has the nurse. Caring for people with autism is exceptionally difficult because of the large number of signs and symptoms which make it difficult for the nurse to approach and take certain actions. The likely nursing diagnosis in people with autism include: disorder of thinking process, memory disturbances, VR for social isolation/loneliness, hopelessness, helplessness, confusion and chronic eating disorder/unbalanced nutrition. The cause of all these nursing diagnosis is the underlying condition/disease or autism. The study was conducted on the small amont of people , so it would be recomended to implement it in all centers for autism in Croatia. It is necessary to be made a categorization of people with autism cared by nurses to determine the need for health care, or the required number of nurses and thereby provide the highest possible quality of life for people with autism.