Hirschsprung's disease (HSCR) is characterized by the absence of ganglia in a specific part of the large intestine. It is most commonly diagnosed in neonates and infants, typically due to symptoms such as constipation, bloating, and vomiting. This paper highlights the importance of knowledge, expertise, and skills of pediatric nurses in caring for children with this congenital malformation. In the preoperative preparation of a child with HSCR, nurses play a key role in ensuring stability before surgery and carry out preparatory measures such as enemas, dietary regimens, and bowel emptying. Postoperative care involves monitoring the child, wound care, stoma management (if present), and educating parents on stoma care and recognizing signs of complications. The paper emphasizes the significance of providing support to parents during this challenging period. Additionally, it presents a case study of a child with HSCR, describing the procedures related to their care and surgery, as well as how the medical staff communicated with the parents.