After the prototype of commercial DSA device has been presented in 1980 this technology started to use in clinical practice with the continuous development and improvement of the technical capabilities of the same. DSA has been considered as a gold standard for blood vessel imaging. The main parts of device are generator, X-ray tube and detector. Generator gives 80-100 kW power and they have ability of pulsed fluoroscopy. Construction of X-ray tube must be adapted. Therefore, anode is built of high-heat capacity material. The heating of the anode is reduced because of its fast rotation and focus ring shape. It has got three focuses and the smallest one is used in fluoroscopy. The latest generation of devices for DSA as image receptor using Flat panel X-ray detector which has high DQE, and its main advantage is the reduced radiation dose for the patient and high quality images. The device is constructed in the form of C arm; commonly used monoplane DSA machine. The main principle of image creation is subtraction of the native images or mask images from the contrast images in order to get the angiogram to see only blood vessels without surrounding tissue. When performing angiography iodine contrast medias are usually used and are applied by automatic injector under certain pressure and speed. Images in digital form on a computer may be later processed. Distance measurement, Windowing, Peristepping, Roadmpping are just some of the programs of postprocessing. Except subtraction device can do 3D-DSA and 3D-FDSA and all images can be displayed as substracted or native images. 3D-FDSA is one of the newest techniques that present the fusion of 3D bone images and 3D blood vessels images. The most common indication for angiography examination is atherosclerosis, tumors, aneurysm, bleeding etc. In any interventional procedures both stuff and patients are exposed to a certain dose of radiation. Therefore is required adherence to all measures od of radiation protection. Bachelor radiological technology is obliged to narrow the widh of primary x-ray beam, reduce the dose of radiation to a minimum following the ALARA principle, should be able to use standard protocols for some examinations, to handle an automatic injector and to know to work on the computer. The whole team is obliged to wear personal protective equipment and dosimeter.