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undergraduate thesis
Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze
2017. urn:nbn:hr:176:547285
Šunjić, Borna
University of Split
University Department of Health Studies

Cite this document

Šunjić, B. (2017). Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze (Undergraduate thesis). Split: University of Split. Retrieved from https://urn.nsk.hr/urn:nbn:hr:176:547285

Šunjić, Borna. "Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze." Undergraduate thesis, University of Split, 2017. https://urn.nsk.hr/urn:nbn:hr:176:547285

Šunjić, Borna. "Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze." Undergraduate thesis, University of Split, 2017. https://urn.nsk.hr/urn:nbn:hr:176:547285

Šunjić, B. (2017). 'Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze', Undergraduate thesis, University of Split, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:176:547285

Šunjić B. Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze [Undergraduate thesis]. Split: University of Split; 2017 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:176:547285

B. Šunjić, "Utjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze", Undergraduate thesis, University of Split, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:176:547285

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Metadata
TitleUtjecaj gadolinijskih kontrastnih sredstava na krvno-moždanu barijeru i nastanak nefrogene sistemske fibroze
Title (english)THE EFFECT OF THE GADOLINIUM,BASED CONTRAST AGENTS ON BLOOD, BRAIN BARRIER AND CREATION OF NEPHROGENIC SYSTEMIC FIBROSIS
AuthorBorna Šunjić
MentorKrešimir Dolić (mentor)
Committee memberIvana Štula (predsjednik povjerenstva)
Committee memberSanja Lovrić Kojundžić (član povjerenstva)
Committee memberKrešimir Dolić (član povjerenstva)
GranterUniversity of Split
(University Department of Health Studies)
Split
Defense date and country2017-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract
Razvojem medicine i tehnologije došlo je i do usavršavanja magnetske rezonancije te ona danas spada u standardne i česte dijagnostičke pretrage. Tijekom snimanja nerijetko je potrebno apliciranje kontrastnog sredstva, radi boljeg isticanja razlika između tkiva i patomorfoloških promjena. Najčešće korištena su gadolinijska kontrastna sredstva. Sastoje se od iona gadolinija i molekule nosača koja se naziva kelat. Strukturno gledano dijele se na linearne i makrocikličke, a po fizičkim svojstvima dijelimo ih na ionske i neionske. Ušli su u kliničku uporabu 1987. godine i od tada se 9 vrsta svakodnevno koristi diljem svijeta. Većina pacijenata nakon apliciranja neće imati nikakve nuspojave, ali oni pacijenti koji otprije pate od neke bubrežne bolesti mogu razviti nefrogenu sistemsku fibrozu. Razvoj ove bolesti zbog utjecaja gadolinijskih kontrastnih sredstava prepoznat je 2006.godine. NSF je sistemska bolest koja se prvo manifestira na koži pacijenta, ali može utjecati i na unutarnje organe. Najveći broj slučajeva NSF-a izaziva neionski, linearni kontrast gadodiamid zvan Omniscan, a u razvoju ove bolesti velik utjecaj ima i doza apliciranog kontrasta. Efikasna terapija za NSF ne postoji, pa se kod rizičnih pacijenata preporuča izvođenje drugih alternativnih pretraga ili korištenje stabilnijih kontrasta u što manjim dozama. 2014.godine je prvi put primijećen abnormalno visok intenzitet signala u nucleusu dentatusu i globusu pallidusu u T1 mjerenoj slici te njegova povezanost s povećanjem kumulativne doze gadolinijskih kontrastnih sredstava. Tada je dokazano da gadolinij ipak prolazi kroz netaknutu krvno – moždanu barijeru i taloži se u mozgu, posebice u nucleusu dentatusu. Većina pacijenata koja su pokazala povećan intenzitet signala na T1 slici primili su linearno kontrastno sredstvo, dok se kod makrocikličkih bilježe neznatne promjene. Dugoročni učinak nataloženog gadolinija na mozak nije poznat i zahtijeva daljnja istraživanja.
Abstract (english)
The development of medicine and technology enabled the advancement of magnetic resonance imaging, which is an often-used diagnostic procedure nowadays. For highlighting the differences between healthy - tissue and pathomorphological changes, a contrast agent is commonly used. Gadolinium is used in magnetic resonance imaging as an MRI contrast agent. It consists of gadolinium ions and a carrier molecule. Structurally there are two types of the agent: linear and macrocyclic, while they can also be divided into two subtypes based on physical properties: ionic and non-ionic. They were first introduced to clinical use in 1987 and since then, 9 different types are used around the world. After applying contrast most of the patients shouldn’t experience any side effects, those with kidney diseases, however, are known to develop nephrogenic systemic fibrosis. The occurrence of this disease caused by gadolinium was first noticed in 2006. NSF is a systematic disease, first manifested on the skin of the patient, but it can also affect other organs. In most cases, NSF is caused by non-ionic linear gadodiamide Omniscan. The development of NSF is also under the influence of applied dose. Since there is no effective therapy for this disease, other alternative procedures are advised in certain risk groups. A high signal intensity in nucleus dentatus and T1 globus pallidus and its correlation with high cumulative dosage of gadolinium contrast agents was first noticed in 2014. It was proven that gadolinium-based contrast agents pass the blood– brain barrier and are deposited in the brain, especially in nucleus dentatus. Most patients that showed a higher signal intensity in T1 imaging had received a linear contrast agent, while others that had received macrocyclic agents showed little to no change. There is no known long-term effect of gadolinium deposition in the brain and the studies should be conducted.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:176:547285
Study programmeTitle: Radiologic Technology (university/undergraduate)
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) radiološke tehnologije (sveučilišni prvostupnik/prvostupnica (baccalaureus/baccalaurea) radiološke tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-05-15 10:01:01