Aim: The main aim of this research is to: examine the differences in knowledge and attitudes, among nursing students at University Department of Health Studies and students at Faculty of Humanities and Social Sciences, towards depressive patients. Method: The research has been conducted in April 2019 on nursing students at University Department of Health Studies (N=34) and students at Faculty of Humanities and Social Sciences (N=43). The questionnaire by which students were interviewed had three parts. In the first part of questionnaire, data about age, sex and study direction of the respondents was collected. The second part of the questionnaire was a knowledge scale about depression, designed for the purpose of this research. The scale consisted of 16 claims, each of which was possible to mark true or false. The third part of the questionnaire was prejudices scale which consisted of 28 claims. The students marked their agreement with each particular statement on a five-point Likert scale Results: The results indicate that a higher percentage of the female gender is present both among the nursing students at University Department of Health Studies (91,4%) and on the Faculty of Humanities and Social Sciences (64,3%). The largest share of students of both faculties is between 21 and 23 years old. In the results of the second part of the questionnaire, which examined the difference in knowledge of nursing students at University Department of Health studies and students at Faculty of Humanities and Social sciences about depressive patients, a statistically significant difference on particles 4 and 10 was determined. 97,1% of nursing students at University Department of Health Studies and 83,3% of students at Faculty of Humanities and Social Sciences knew that particle 4. Depressive patients are aggressive is incorrect. 73,5% of nursing students at University Department of Health Studies and 90,5% of students at Faculty of Humanities and Social Sciences knew that particle 10. Depression can have psychotic elements too is true. Also, statistically significant differences in degree of prejudices among nursing students at University Department of Health Studies and students at Faculty of Humanities and Social Sciences were determined on the following particles: 1. I would make contact with a depressive patient on my own initiative, 11. Someone can be a depressive patient and a good man at the same time and 20. Depressive patients have to take medicines for lifetime. It is only on the first mentioned particle that the nursing students at University Department of Health Studies showed their less pronounced prejudices than the students at Faculty of Humanities and Social Sciences. On the others of the mentioned particles, students at Faculty of Humanities and Social Sciences have less pronounced prejudices towards depressive patients than the nursing students at University Department of Health Studies. Conclusions: In conclusions of our research we can determine that nursing students at University Department of Health Studies and students at Faculty of Humanities and Social Sciences have high level of knowledge about depressive patients, but nursing students at University Department of Health Studies did not show that they have more knowledge than students at Faculty of Humanities and Social Sciences. Equally, paying attention to the prejudices, students at Faculty of Humanities and Social Sciences showed a lower level of prejudices towards depressive patients in comparison with nursing students at University Department of Health Studies. For all the above reasons, our hypothesis that nursing students at University Department of Health Studies will have greater knowledge and less pronounced prejudices towards depressive patients than students at Faculty of Humanities and Social Sciences, is rejected.